"Reversed" alamethicin conductance in lipid bilayers
نویسندگان
چکیده
منابع مشابه
Calcium-induced inactivation of alamethicin in asymmetric lipid bilayers
This paper discusses a calcium-dependent inactivation of alamethicin-induced conductance in asymmetric lipid bilayers. The bilayers used were formed with one leaflet of phosphatidyl ethanolamine (PE) and one of phosphatidyl serine (PS). Calcium, initially confined to the neutral lipid (PE) side, can pass through the open alamethicin channel to the negative lipid (PS) side, where it can bind to ...
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Using dilatometry and small-angle X-ray diffraction, we have studied under bulk conditions the structural changes and elastic response of dioleoyl phosphatidylcholine bilayers to alamethicin. With increasing peptide concentration, we found a progressive thinning of the membrane. However, in contrast to previously published reports, this thinning exhibits exponential behavior. Furthermore, an in...
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We have investigated the x-ray scattering signal of highly aligned multilayers of the zwitterionic lipid 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine containing pores formed by the antimicrobial peptide alamethicin as a function of the peptide/lipid ratio. We are able to obtain information on the structure factor of the pore fluid, which then yields the interaction potential between pores i...
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The antimycotic activity of amphotericin B (AmB) depends on its ability to make complexes sterols to form ion channels that cause membrane leakage. To study this phenomenon, surface pressure (pi) as a function of surface area (A) and pi-A hysteresis were measured in monolayers of AmB-cholesterol mixtures on the water-air interface. The most stable monolayers were produced from molecules of AmB ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1991
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(91)82299-8